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The Georgicks of Virgil, with an English Translation and Notes Virgil, John Martyn Ipsi in defossis specubus secura sub alta Otia agunt terra, congestaque robora, Pierius says it is confecto in the Roman manuscript. And Tacitus also says the Germans used to make caves to defend them from the severity of winter, .

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Lancet Neurol ; 10 : Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features. BMC Psychiatry ; 12 : Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: Specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry ; 70 : Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry ; 19 : Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study.

Lancet ; : Pseudopseudoseizures: conditions that may mimic psychogenic non-epileptic seizures. Psychosomatics ; 52 The frequency of autoimmune N-methyl-D-aspartate Clin Infect Dis ; 54 : Treatment and prognostic factors for long-term adolescent.

Table of contents

J Child Neurol ; 27 : Lancet Neurol ; 12 : Frequency and characteristics of isolated bipolar disorder. Psychiatry Res ; : JAMA Neurol ; 70 : Anti-NMDA receptor encephalitis: report of ten cases and neuropsychiatric disorders and in dementia patients. Eur Arch Psychiatry comparison with viral encephalitis.

Clin Neurosci ; : N-methyl-D-aspartate receptor antibodies in herpes simplex Antibodies to the glutamate encephalitis. Ann Neurol ; 72 : Bipolar Disord ; 14 : Mechanisms underlying autoimmune synaptic encephalitis Lauvsnes MB, Omdal R. Systemic lupus erythematosus, the brain, and anti- leading to disorders of memory, behavior and cognition: insights from molecular, cellular and NR2 antibodies. Eur J Neurosci ; 32 : Disrupted surface cross-talk Brain J progression of clinical and paraclinical observations in a predominantly non-paraneoplastic Neurol ; : Brain ; : Lack of anti-NMDA receptor Antibody titres at diagnosis and during follow-up of autoantibodies in the serum of subjects with schirophrenia.

Lancet Neurol ; 13 : Anti-NMDA-receptor encephalitis in a 3 year old patient with Investigation of antibodies chromosome 6p Eur J Paediatr Neurol ; 15 : against synaptic proteins in a cross-sectional cohort of psychotic pateints. Schizophr Res ; : Suppression of synaptic plasticity by cerebrospinal fluid from Gielen M.

Neurobiol Dis ; 45 : Paris ; 26 : Jacob L, Dauvilliers Y. La narcolepsie : une maladie auto-immune? Med Sci antibodies in patients with schizophrenia and related psychoses: a systematic review and meta- Paris ; 30 : Psychol Med ; 44 : Titulaer MJ, Dalmau J. Antibodies to NMDA receptor, blood-brain barrier disruption and schizophrenia: a theory with unproven links.

Neuroinflammation and psychiatric illness.

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J Neuroinflammation ; 10 : Les causes primitives des atteintes mezni. Or, si ces obser-Tableau I. Humphreys et al. Nous avonstubulaires [3]. Conclusion 2. J Am Soc Nephrol ; 10 : Hinz B. The myofibroblast: paradigm for a mechanically active cell. Les cel- Biomech ; 3 : Wynn TA. Cellular and molecular mechanisms of fibrosis. La liste des facteurs extracellulaires et intra- Strutz FM. EMT and proteinuria as progression factors.

Cette liste offre aussi une source impor- Epithelial-to-mesenchymal transition andavoir un impact, important pour le patient, en termes de pronostic, de chronic allograft tubule interstitial fibrosis. Transplant Rev ; 22 : Zeisberg M, Kalluri R. J Mol Med ; 82 : The epithelial-mesenchymal transition and fibrosis of the renaltransplant 8.

Mesenchymal transition in kidney collecting duct epithelial cells. Epithelial-mesenchymal transition EMT is a process by which diffe-rentiated epithelial cells undergo a phenotypic conversion and acquire 9. Soluble HB-EGF induces epithelial-a mesenchymal phenotype, including elongated morphology, enhanced to-mesenchymal transition in inner medullary collecting duct cells bymigratory and invasion capacity, and greatly increased production upregulating snail This phenomenon playsa pivotal role in embryonic development, wound healing and tissue Kalluri R, Weinberg RA.

The basics of epithelial-mesenchymal transition. It has also been involved in organ fibrosis. Some studies J Clin Invest ; : Evidence that fibroblasts derive fromsource of de novo myofibroblasts invading the renal interstitium and epithelium during tissue fibrosis. J Clin Invest ; : However, an increasing number of studies raisedoubts about the existence of this process in vivo. The role of EMT in A proximal activator of transcription inthe development of renal fibrosis remains a matter of intense debate epithelial-mesenchymal transition.

In this review, we describe therole of EMT in the development of fibrosis of renal graft, and then we Integrated actions of transforming growthpropose approaches for detecting and treating renal fibrogenesis by factor-E1 and connective tissue growth factor in renal fibrosis. Am J Pathol ; : Autophagy is a component of epithelialpar le CMCU sous forme de bourse doctorale. Nous remercions Campus France cell fate in obstructive uropathy. Cook T. The origin of renal fibroblasts and progression of kidney disease.

Banff 07 classification of renal allograft pathology: updates Pallet N, Anglicheau D.

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Am J Transplant ; 8 : A case report suggesting the occurrence of epithelial-mesenchymal transition in obstructive nephropathy. Clin Exp Nephrol ; 13 : Early epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol ; 19 : The differential expression of TGF-E1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study.

Int J Clin Exp Pathol ; 9 : Early activation of fibrogenesis in transplanted kidneys: a study on serial renal biopsies.

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Exp Mol Pathol ; 87 : Protocol biopsy program after renal transplantation: structure and first results. Transplant Proc ; 34 : Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant ; 5 : Risk factors for early epithelial to mesenchymal transition in renal grafts. Am J Transplant ; 6 : Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int ; 62 : Galichon P, Hertig A. Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?

Fibrog Tis Rep ; 4 : Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis. Hum Pathol ; 39 : Molecular basis of organ fibrosis: Potential therapeutic approaches. Exp Biol Med ; : Perspectives on blockade of TGF-beta 1 overexpression. Kidney Int ; 69 : Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med ; Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis. Liver Int ; 26 : Klahr S. The bone morphogenic proteins BMPs : their role in renal fibrosis Kidney Int ; 66 : J Nephrol ; 16 : Transforming growth factor-beta 1 antisense Regarding the mechanism of action oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction.

Kidney Int of a proposed peptide agonist of the bonmorphogenetic protein: receptor ; 58 : Nat Med ; 19 : Natural inhibitor of transforming growth factor-beta Yang J, Liu Y. Blockage of tubular epithelial to myofibroblast transition protects against scarring in experimental kidney disease. J Am Soc Nephrol ; 13 : Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. La fibrose tubulo-interstitielle J Am Soc Nephrol ; 14 : Med Sci Paris ; 27 : Med Sci Paris attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ- ; 29 : Diabetes ; 45 : Long-term prevention of renal insufficiency, excess matrix I.

Code postal Ville Ladans les maladies inflammatoires et tumorales. Ces Figure 1B. A NES? TSC-box Figure 1.

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Ainsi, le domaine amino-terminal les ganglions lymphatiques et le thymus [1]. Il serait cell death. Immunity ; 7 : FEBS J ; : Transforming growth factor- beta-stimulated clone is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. Ayroldi E, Riccardi C. Glucocorticoid-induced leucine zipper GILZ : a new important mediator of glucocorticoid action. Faseb J ; 23 : Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC Interaction between fortilin and transforming growth factor-beta stimulated clone TSC prevents apoptosis via the destabilization of TSC FEBS Lett ; : TSC promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

Mol Cell Biol ; 31 : J Biol granular lymphocyte leukemia. Down-regulation of TSC GILZ promotes production of peripherally induced Treg transforming growth factor beta-stimulated clone 22 markedly enhances cells and mediates the crosstalk between glucocorticoids and TGF-beta signaling. Cell Rep ; the growth of a human salivary gland cancer cell line in vitro and in vivo.

Cancer Res ; 58 : Transforming growth factor-beta-stimulated clone Oncogene ; 31 : Mechanism of apoptotic cell death of Cytoplasmic TSC transforming growth factor-beta- human gastric carcinoma cells mediated by transforming growth factor stimulated clone markedly enhances the radiation sensitivity of salivary gland cancer cells. Identification of glucocorticoid Glucocorticoid-induced leucine zipper induced leucine zipper as a key regulator of tumor cell proliferation in GILZ promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner.

J Biol Chem ; epithelial ovarian cancer. Mol Cancer ; 8 : Glucocorticoid-induced leucine zipper Molecular cloning and characterization of a transcription factor GILZ over-expression in T lymphocytes inhibits inflammation and tissue for the C-type natriuretic peptide gene promoter. Eur J Biochem ; : Neurotherapeutics ; 9 : FoxO3 mediates antagonistic effects Srinivasan M, Janardhanam S.

Novel p65 binding glucocorticoid- of glucocorticoids and interleukin-2 on glucocorticoid-induced leucine zipper expression. Mol induced leucine zipper peptide suppresses experimental autoimmune Endocrinol ; 19 : GILZ expression in human dendritic cells redirects their Induction of antigen-specific regulatory maturation and prevents antigen-specific T lymphocyte response.

T lymphocytes by human dendritic cells expressing the glucocorticoid- induced leucine zipper. Dexamethasone and IL stimulate glucocorticoid-induced leucine zipper synthesis by human mast cells. Allergy ; 61 : Synthesis of glucocorticoid-induced leucine zipper T-cells in respiratory allergies. Allergy ; 69 : GILZ by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL Glucocorticoid-induced leucine zipper is downregulated in fertility.

Mol Endocrinol ; 26 : Eur J Immunol ; 42 : Long glucocorticoid-induced leucine Glucocorticoid-induced leucine zipper is an endogenous zipper L-GILZ protein interacts with ras protein pathway and contributes antiinflammatory mediator in arthritis.

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Arthritis Rheum ; 62 : Upregulations of glucocorticoid-induced leucine zipper by hypoxia Recombinant long-glucocorticoid- and glucocorticoid inhibit proinflammatory cytokines under hypoxic conditions in macrophages. Eur J Pharm Sci ; 63C : Post-transcriptional up-regulation of Tsc by Ybx1, a target of miRa, mediates TGF-beta-induced collagen expression in kidney cells. Figure 3. Encapsulation et analyse par dPCR en microgouttelettes. Des plate-formesKiss et al. Derares [31]. Se widely used in laboratory settings.

Microfluidics offers promising tools to isolatenote 1 [43]. DNA fragments such as microdroplets, microchambers or microwells with volumes ranging from few picolitersConclusion to nanoliters. Taly et P. Quantitative cell-based reporter gene assays using droplet-based microfluidics. Chem Biol ; 17 : Sawyers CL. The cancer biomarker problem. On-chip single-copy real-time reverse-transcription PCR in isolated picoliter droplets.

Anal Chem ; monitoring during amplification. Biotechniques ; 24 : Detection of specific polymerase chain reaction Proc fluorescence imaging for digital PCR. Lab Chip ; 11 : High-throughput quantitative mutations from circulating tumor DNA. Nat Med ; 20 : Anal Chem ; 80 : 5. Quantitation of targets for PCR by use of limiting dilution. Biotechniques ; 13 : Vogelstein B, Kinzler KW. Digital PCR.

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Quantitative and sensitive detection of rare 7. High-throughput droplet digital PCR system for mutations using droplet-based microfluidics. Anal Chem ; 83 : Tolerance of droplet-digital PCR versus real-time Clin Chem ; 59 : Baker M. Digital PCR hits its stride. Nat Methods ; 9 : Med Sci Paris ; 25 : Diaz LA, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Nanoliter high throughput quantitative PCR.

Nucleic Acids Res Oncol ; 32 : Microfluidic large-scale integration. Science ; : Comparative study of sensitivity, Transcription factor profiling in individual linearity, and resistance to inhibition of digital and nondigital polymerase hematopoietic progenitors by digital RT-PCR. Single-molecule detection of epidermal growth factor quantification of human cytomegalovirus. Anal Chem ; 86 : De haut en bas : le supra-epineux supraspinatus , l'infra-epineux infraspinatus , le petit rond teres minor et le grand rond teres major. From the top to the bottom : supraspinatus, infraspinatus, Teres minor, Teres major.

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