The BioRegionUlm is a biopharmaceutical site with international standing. Between Ulm and Lake of Constance an outstanding and long established experience has been focussed on the development and production of biopharmaceuticals particularly with mammalian cell culture, including the fill and finishing. Main topics in this bioregion are biotechnology and biomedicine , medical technology and nanotechnology. The bioregion and the IGZ are located at the Science Park in Wuerzburg, an area of 70, square meters reserved for the settlement of high-tech companies and service providers located in the east of Wuerzburg.
Here, some 2, square meters of laboratory space with adequate technical infrastructure, and about 3, square meters of office space are available for high-tech companies. The bioregion benefits from its proximity to the university and university hospital, the university of applied sciences, and numerous research facilities.
Independent from public funding, the initiative is financed by its members. Objectives: BioRiver catalyses intensive knowledge transfer between academic research and companies and sees to an additional marketing for the members and the region. Furthermore the organisation successfully aims to improve the political awareness and financial general conditions. Many of the BioRiver projects stand out by their making in cooperation with local, regional or other partners. BioRN Network association consists of a network of about 80 science and industry partners. It promotes the development of the Rhine Neckar reBioRN Network association consists of a network of about 80 science and industry partners.
It promotes the development of the Rhine Neckar region into one of the leading life-science clusters in Europe. Its main goal is the empowering of innovative forces to strengthen the international competitiveness as well as the creation and coordination of joint projects across Europe. The members represent the various life science companies, research centers and representatives of the sector in Saxony. The aims of biosaxony e. The Cluster for Individualized ImmuneIntervention Ci3 bundles the outstanding expertise in the Rhine-Main cluster region in the area of biotechnology-based individualized medicine focusing on immune therapies and diagnostics.
Ci3 is the integrative element across the entire value chain, from early innovation to production, marketing and application, and connects more than stakeholders from industry, research, medical care providers and politics. Freiburg BioRegion, an attractive and dynamic region offering a high quality of life, is located in Germany but is close to both France and Switzerland. The Berlin-Brandenburg region is one of the leading life sciences and healthcare industries centers in the world.
Numerous technology parks and networks in different fields, above all biotechnology and medical technology, create an ideal infrastructure for transforming the latest scientific findings into innovative products for the healthcare sector. HealthCapital is the central contact and coordination office for all issues concerning biotechnology in the German capital region. As a leading Biotechnology Center in Europe, Hessen offers unsurpassed opportunities for the biotechnology industry — a concentrated network of higher education and research institutes combined with a vast pool of highly qualified life sciences personnel.
The InfectoGnostics research campus is a public-private partnership developing new methods in infection diagnostics. In a triad of technology, application and production, more than 30 partners from science, medicine and industry are developing marketable solutions for rapid and cost-effective on-site analysis point-of-care testing of infections in human medicine, animal diseases, and pathogen detection in food. In Thuringia there are approx. With about 50 medical technology companies and suppliers, the medical technology sector is one of the most innovative in Thuringia.
The field is deeply rooted in traditional industries such as optics, precision engineering and pharmaceutical industries. Universities, research institutes, and clinics are available to collaborate with corporate partners. The two North German states of Schleswig-Holstein and Hamburg stand out for their broad base of companies and for the presence of a complete value chain in the life sciences.
As an additional benefit, the association offers its supporting members a partner programme in cooperation with the cluster management. The cluster organization Life Science Nord Management GmbH initiates strategic projects and supports the promotion of companies, science and institutes with an emphasis on innovative medicine. As a cluster management, it connects business and research in the north, thereby bringing to companies the expertise from universities and research facilities as well as its network of close contacts.
Additionally, the management is responsible for representing the regional life sciences on national and international levels. The non-profit association was founded to enhance the communication between research, economy, politics and the public. Our goal is to:. The Techologiepark Heidelberg was founded in as the first science park in Germany with a life science focus. Through its growth in the fields of biotechnology, pharmatechnology, environmental technology, printed electronics, as well as IT, it has been able to expand into five locations. The Technologiepark supports the exchange between research and industry and spin-offs from science with the necessary infrastructure.
By working closely with internationally active partners, it offers local businesses a large network. Profile Bioregion BioIndustry e. Profile Bioregion BIO. Christian Andersen, Dr. Location Heidelberg Contact Person Dr. Profile Bioregion biosaxony e. Website www. Is a communication platform: Organizing cooperative booths at international trade fairs as well as symposiums, workshops and congresses on current biotechnology discussion topics.
Hinrich Habeck Managing Director Dr. Profil Bioregion MedLife e. Profile Bioregion NanoBioNet e. Our goal is to: create new, innovative, and marketable products and workplaces, create and provide nanobiotechnological teaching contents for all education levels, support research and development inform the public about the exciting world of nanobiotechnology. Our key issues are chemical nanotechnology nanobiotechnology pharmaceutical biotechnology and nanoethics and nanosafety. Medical Biotechnology and biopharmaceuticals: recombinant proteins, protein engineering, protein biochemistry, molecular biology, biopharmaceutical development and production of veterinary and human vaccines and pharmaceuticals, development of new therapies for autoimmune and neurodegenerative diseases, immunodiagnostics, clinical studies Plant biotechnology and plant breeding: plant genetics, crop plant research, marker-assisted breeding, biopharming, energy plant research Industrial biotechnology: industrial use of renewable ressources, sustainable production of biopolymers and related products, development of novel technical enzymes, microalgae as ressources of biomass and high-value products.
BioLAGO e. CLIB e. Interaction from Biotechnology, Pharmaceutical industry, Medical technology, Energy, Chemical industry and Environmental technology. These are products which can be used as a basis to produce a multitude of chemicals. This are the first steps into industrial biotechnology. His tasks there include the scientific direction of the prototyping laboratory of the chair. He studied electrical engineering at the Technical University of Berlin and wrote his thesis on telemedicine and remote monitoring of vital signs.
His research focuses on embedded systems and especially reliable wireless sensor systems. Honeybees are irreplaceable key organisms in agriculture due to their pollination capacity. However, complex changes in the environment over the last few decades are increasingly presenting problems for a healthy, area-wide bee population.
The bee deaths that have been observed worldwide for decades are leading to a steady reduction of the bee population. At the same time, the world's population is growing exponentially. Even with a constant bee population, this implicitly results in an exponential dependence of humans on the pollination performance of bees.
The external strains and threats of bee colonies require regular condition checks by the beekeeper. However, this in turn is itself a stress for the bees and leads often to disturbed self-regulation homeostasis of the bee colonies. For example, each opening of a beehive for control purposes can result in a loss of yield of up to 1 kg of honey. Much more significant, however, is the stress that the bees are subjected to during every regular inspection of the colonies.
The technology used must remain unobtrusive and the beehive must not become a control cabinet. This infrastructure must not only be easy to install and operate, but also very affordable. In the project, reliable miniaturized and energy-efficient sensors are to be developed using COTS components within the framework of a technology transfer from space technologies to the terrestrial sector. Since he is doing his PhD at the Helmholtz Centre for Environmental Research on the anaerobic digestion microbiome in a combined experimental and computational approach.
Several hundred cases of acidification are estimated to occur in German biogas plants annually. In the best case, plants can recover but are faced with economic losses of several thousand euros. In the worst case, the process biology breaks down completely, resulting in months of downtime and substantial economic losses.
In our research project, we develop an additive that allows a fast and cost-efficient recovery of acidified biogas plants. Furthermore, we develop an additive to accelerate the start-up of new plants that are located too far from conventional inoculum sources. PD Dr. In she earned her habilitation and has received the venia legendi to teach in the field of plant protection and plant health. Her scientific expertise includes the fields of plant diseases, integrated plant protection and plant phenotyping. In her research she puts special emphasis on the application of optical sensors assessing plant diseases and defence reactions.
She serves internationally and nationally as reviewer for scientific journals and funding institutions. The detection and identification of plant diseases is crucial for an appropriate and targeted application of plant protection measures in crop production and or for a selection of resistance genotypes. Recently, intensive research has been conducted to develop innovative and technology based optical methods for plant disease detection. In contrast to common visual rating and detection methods, optical sensors are able to measure pathogen induced changes in the physiology of susceptible or resistant plants non-invasively and objectively.
Especially hyperspectral sensors are valuable tools for disease detection, identification and quantification on different scales from the tissue to the canopy level. Within this context, the detection of subtle resistance reactions is even more challenging. Thus the CropSense. Possible applications of hyperspectral sensors on different scales for disease detection and plant breeding have been evaluated. The advantages and disadvantages on each particular scale were critically considered.
Based on an approaches by a combination of expertise from plant pathology, electrical engineering, informatics and advanced data analysis, detection of primary infection sites or defence reactions — even before visible symptoms appear — was feasible. The potential of hyperspectral sensors as a tool for resistance screening and disease identification, based on characteristic changes in the plants spectral signature, could be underlined.
Future research also has to consider improved sensor platforms and vehicles for field and high-throughput applications. It is expected, that new developments in the field of robotics will speed up the integration into agricultural practice. Sven Grasselt-Gille is married and has three children. In he finished his studies at TU Dresden in Mechanical Engineering, specializing in industrial design and aerospace engineering. There he is working on the development of products made from natural fiber materials since Aid organizations depend on the provision of cots in immense numbers to respond to multiple disaster scenarios as populations grow.
Above all, the required equipment must be cheap, easy to transport and easy to dispose of. Current designs meet these and other core requirements of modern humanitarian aid insufficient. They have additional disadvantages such as unstatisfactory ergonomics and long logistics chains and are designed for multiple uses, which is the exception in practice. Thus a high expenditure of resources is offset by a low utility value. Within the framework of the BMBF project "EFB - Disposable cot from renewable resources for humanitarian aid" a product solution is de-veloped, which basic premises are the design for one-time transpor-tation and construction from renewable resources.
Further require-ments are to improve the ergonomics for all user groups and limiting the costs to a competitive level. Thanks to the fundamental re-design the previous project goals were met in full extent. By using technologies of the packaging industry, it is additionally possible to manufacture large quantities in a short time, as required by flexible production. In the next stage of development, field tests in cooperation with relief organisations will serve to quantify the products benefits. His scientific research areas are gene technology, genome analysis, and application of Genome Editing in trees.
Safeguarding and increase of crop yield, quality of plant raw materials and sustainability in plant production requires new approaches in research and breeding. In the EU, there are 4.
Set-aside agricultural land is usually nutrient-poor, and these nutrient-poor soils are suitable for growing trees as energy crop since trees show a high nutrient-efficiency and it is not necessary to fertilize trees in short rotation plantations. A Genome Editing approach was also evaluated in this project. Subsequently, it was shown that both genes have an influence onto biomass formation in Arabidopsis.
By overexpression of SOC1 and FUL, their influence onto biomass formation was verified also in poplar in a proof of concept approach. Here, growth of poplar and thus biomass formation was extremely disturbed. In a complement approach, increase of biomass formation is in focus through knockout of five paralog genes of SOC1 and FUL. Further, phenotypic modified poplars were achieved by genetic modification of PCBER1, an oxidoreductase gene catalyzing a certain step of lignan biosynthesis.
While overexpression of PCBER1 in transgenic poplar lines revealed significantly modified wood composition, knockdown of this gene led to significantly increased plant height and slightly modified wood composition. Peter Nick studied Biology in Freiburg. After his Ph. After returning to Freiburg to complete his habilitation , funded by the Deutsche Forschungsgemeinschaft, he obtained a Junior Research Group by the Volkswagen Foundation and accepted a professor position at the Technical University of Karlsruhe in Since , he is editor-in-chief of Protoplasma Springer , the cell biology journal with the longest tradition.
He is heading a group with currently 25 Ph.
Serie: Genetics and Society
Plants can synthetise more than a million of so called secondary compounds. What for? Since they cannot run away, plants have chosen the evolutionary strategy to manipulate other organisms for their purpose. Many of these compounds have there also an effect on humans and represent the molecular base for the healing activity of many plants. Since several years we work on production of these secondary compounds in cell cultures to obtain a sustainable alternatives for the collection and extraction of frequently endangered and rare plants. However, often these compounds are not made in cell culture, because plant chemistry is team work, where different cells have to cooperate.
This "metabolic LEGO" is hard to simulate in a biofermenter. To get a biotechnological copy of cellular cooperation, an interdisciplinary cooperation of scientists Botanical Institute and Institute for Microstructure Technology, both Karlsruhe Institute of Technology, Phyton Ahrensburg as industrial partner was established to develop a microfluidic biofermenter for plant cells. We were able to show that modular combination of different cell types can release hidden metabolic potencies. We also were able to show that a careful analysis of cellular aspects in a biofermenter is crucial for application.
Bio-based antimicrobial substances — an opportunity for a new kind of detergent? Henrike Brundiek is a trained biotechnologist with strong expertise in enzyme expression and protein engineering. Currently, laundry is performed in shorter and colder washing cycles.
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This has provoked a lower level of sanitization in clothes after washing especially in central and northern European countries. Therefore, HYGIENZYM has investigated the creation of a novel bifunctional detergent able to wash and sanitize cloths using the capacity of certain commercial and non-commercial enzymes as well as compounds of essential oils as antimicrobial agents. During the project, two antimicrobial enzymes were identified to be of special interest: a haloperoxidase, which was previously not commercially available, and shows a broad antimicrobial spectrum and the enzyme lysostaphin, which is especially active against staphylococci, including the MRSA germs.
These enzymes were produced cost-effectively in a secretory form in Pichia pastoris.
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In addition, a bacterial lactoperoxidase with potentially antimicrobial properties was prepared on a laboratory scale, too. Since the peroxidase system is a complex tripartite system, first plant extracts with antimicrobial activity were used for the proof-of-concept work on the new detergent formulation. Finally, a new two-chamber film technology could be employed for the formulation of the novel liquid detergent with the capacity to sanitize clothes during washing.
Hence, Hygienzyme has investigated sucessfully novel washing concepts which are in line with greener washing habits. Research focus are the next generation of sensor systems NGS , the Computer Vision for biological samples and laboratory automation for the Lab of the Future. From to , he joined the plant automation industry. From to , he did his PhD at the chair of Bioprocess Engineering at the TU Dresden in the field of growth modeling of plant in vitro cultures. Felix Lenk authored several peer-reviewed publications as well as two book chapters and holds 7 patents.
Standard sensor probes represent a measured value only in one spot of the bioprocess. While those measurements depict accurately the conditions in the bioreactor for homogeneously mixed processes, heterogeneities in not ideally mixed reactors cannot be detected.
Furthermore, the integration of such rod-shaped, wired probes pose a problem when it comes to reactors in which sensor ports are not provided due to design limitations e. We present a new approach, the Sens-o-Spheres. Omitting the cable connection while condensing the whole sensor geometry to a small sphere of only 8 mm in diameter allows a flexible usage.
The re-usable sphere consists of a data and a charging antenna, a micro-controller for the functional coordination, a rechargeable battery all within a laser welded encapsulation for the use in biotechnological processes. Onto this sensor platform a temperature sensor is mounted. This spherical measurement device moves through the process volume independently and transmits the recorded measuring values wirelessly via radio frequency waves to a receiver.
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Mobile sensors like the Sens-o-Spheres provide the opportunity to investigate heterogeneities and make measuring much simpler. With the integration of further measurements such as pH-value and dissolved oxygen concentration, the Sens-o-Spheres will be a powerful tool towards the new bioeconomy. Nadja Kreuter was born on June 26th in Koblenz, Germany. In , she completed her state exam at the Landesbetrieb Hessisches Landeslabor in Wiesbaden as a nationally certified food chemist. The characteristic aroma profile of e. Provolone is achieved by addition of calf, kid coat, or lamb pregastric esterases to the cheese milk.
Due to the demands of vegetarians and a growing market of kosher and halal-certified products, alternative lipases e. In a broad screening, various mushrooms were tested in submerged cultures for the secretion of appropriate lipases. The cultivation parameters of the most promising mushrooms were optimized to increase the secretion of extracellular lipases.
The lipases were purified from the supernatants by means of foam fractionation, ammonium sulfate precipitation and fast protein liquid chromatography. Application tests of promising enzymes were carried out in cooperation with the project partner optiferm GmbH. The cheeses were ripened for 30 days and then stored for another 12 weeks. A GC-MS-based method was developed and the produced cheeses were tested for the presence of free fatty acids by solid phase microextraction coupled to gas chromatographic analysis using mass spectrometric detection. Sustainable adaptation of coastal agro-ecosystems to increased salinity intrusion DeltAdapt.
His research addresses the fate of priority pollutants in terrestrial systems, nutrient cycling in soil, and the non-invasive sensing of soil properties.
Sustainable Development Knowledge Platform
In the Mekong and Red River Deltas, Vietnam, farmers react to the salinity intrusion by many ways such as shifting from paddy rice to rice-shrimp farming and saline aquaculture, associated with increasing investment costs, unknown changes in soil fertility and greenhouse gas evolution.
Other farmers or family members migrate for work or sell their topsoil to generate immediate income, which complicates the options to reverse these trends. In the DeltAdapt project, a consortium of German and Vietnamese scientists evaluated the extent, risks and opportunities of these changes along salinity gradients in both deltas. Shifting from paddy rice to rice-shrimp farming impaired soil fertility much less than direct conversion to saline aquaculture, whereas preventing salinity intrusion by using dykes increase soil pollution with pesticides towards the dyke.
On larger scale, novel aquaculture — cropping rotations like integrated rice-shrimp farming or intelligent rice-vegetable or rice —fish systems could provide climate-smart and profit-orientated solutions, if remaining flexible and integrated into landscape-scale land-use planning. If wisely managed on large scale and underpinned by insurance systems, the threat of salinity intrusion may thus finally convert into an opportunity towards an adapted, sustainable coastal agro-ecosystem management with improved livelihoods.
Since he is working in scientific research and education of forest operations and biomass supply at various institutions. In the light of climate change and societal interests, forests are under change from coniferous to deciduous tree species. Today, deciduous species are by far lesser used for any material application than coniferous species.
This offers a great chance specifically for new applications in the field of Bioeconomy. However, there is a lack of precise forest operation technology for harvesting deciduous species, since the development focused on coniferous species for the last decades. The joint-cooperation project HIPHAR focused on operation technology that enables foresters to supply wood fully-mechanized with a low impact on the environment, a reduced work strain, but a maximum yield of resources.
Four independent developments were realized within the project: a bogie-axle with track-supporting roller to increase the effective area of contact, a harvester head specifically to fell and process large dimensions of deciduous trees, a position and navigation system under forest conditions, and a new designed machine cabin including steering. Field studies and experiments at test stands were performed, gaining promising results that support the concept ideas. With the new bogie-axle the effective contact surface area was significantly increased leading to a higher number of passable drives on sensitive forest soils at reduced rut creation.
The designed harvester head has a completely different feeder device that enables operators to follow the buckled shaft of deciduous species. The mounted top and bottom saw allow a maximum yield of the valuable trunk. Further tests of the developments are envisaged to make the technology ready for the market.
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Matthias Zscheile, BioEconomy Cluster. Juni in Halle Saale. Abstract Biorefineries are considered a central element in the transition to a bioeconomy, since they promote an efficient use of biological resources and allow for production of a wide spectrum of biobased products, including fuels, chemicals and materials. Abstract The talk will analyse and compare new path creation in three Norwegian regions specialised in forest-based value creation. Coffee Break.
Abstract Bioclusters are expected to play an important role in the transition toward a bioeconomy. Frans Hermans Photo: Markus Scholz. Abstract In recent years the German government has fostered the integration among the different industrial sectors working in the bioeconomy field. Abstract The presentation would like to introduce the European landscape of research funding opportunities, in particular the 8th EU Research Framework Program for Research and Innovation Horizon Claudia Weinhold Photo: Privat.
Abstract Dry-jet wet spinning using 1,5-diazabicyclo[4. References 1 Asaadi, S. Herbert Sixta Photo: Privat. Abstract The forest industry has long been part of the economic back-bone of the Scandinavian countries, but is also very important in other regions of Europe. Abstract Forest industry is developing new process concepts for production of novel value added products. Biography Dr. Abstract Organic farming is facing various challenges, among them the responsible use of admitted plant protecting agents.
Abstract Chemistry 4.
Ulrich Blum Photo: Private. Abstract Whole plant phenotyping integrated with genotyping and molecular profiling is used to uncover determining factors and mechanisms of plant growth performance. Thomas Altmann Photo: Sam Rey. Abstract Site-directed genome modification triggered by customizable endonucleases offers novel possibilities for the elucidation of gene function and the improvement of crop performance. Jochen Kumlehn Photo: Privat. Abstract The Chair of Plant Breeding at the Martin Luther University Halle-Wittenberg has a strong research focus on applying state of the art plant science technologies to molecular breeding of the cereal crops barley and wheat.
Andreas Worberg Photo: Privat. Abstact Sustainable Davids and Greening Goliaths — A Tale of Technology Innovation and Diffusion The diffusion of technology innovations can be understood as a process of communication among different participants in a social system over time. Ronny Kittler Photo: Private.
Abstract Finland was one of the first countries in the EU to develop its dedicated bioeconomy strategy, which was adopted by the government in Mika Aalte Photo: Privat. Abstract Many biotechnology companies are specialized on the use of metabolic engineering to develop designer bugs for the fermentative production of ingredient products for instance for the food and personal care industry.
Marc Struhalla Photo: Privat. Abstract Within only five years, JeNaCell developed from a science-based start-up to a certified medical producer of pioneering products for burns and other skin injuries with a production capacity in ton-scale. Abstract The use of renewable raw materials as an alternative to fossil resources is gaining in importance in the chemical industry.
Joachim Schulze Photo: transmedial. Lunch Break. Abstract Honeybees are irreplaceable key organisms in agriculture due to their pollination capacity. Alexander Hilgarth Photo: Privat. Abstract Several hundred cases of acidification are estimated to occur in German biogas plants annually.
Fabian Bonk Photo: Privat. Abstract The detection and identification of plant diseases is crucial for an appropriate and targeted application of plant protection measures in crop production and or for a selection of resistance genotypes. Abstract Aid organizations depend on the provision of cots in immense numbers to respond to multiple disaster scenarios as populations grow.
Sven Grasselt-Gille Photo: Privat. Abstract Safeguarding and increase of crop yield, quality of plant raw materials and sustainability in plant production requires new approaches in research and breeding. Matthias Fladung Photo: Privat. Abstract Plants can synthetise more than a million of so called secondary compounds. Peter Nick Photo: Privat. Henrike Brundiek Enzymicals AG Bio-based antimicrobial substances — an opportunity for a new kind of detergent?
Abstract Currently, laundry is performed in shorter and colder washing cycles. Henrike Brundiek Photo: Privat. Abstract Standard sensor probes represent a measured value only in one spot of the bioprocess.