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Marzi, D. Because of its morphology, it is also called geographical atrophy. She's the more aggressive form of the disease. The phagocytic function of the retinal pigment epithelium decreases with age. The result is lipofuscin deposits in the RPE cells.
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (TERM).
- UKGM Gießen/Marburg - Team;
- Public Education about Cancer: Research findings and theoretical concepts (UICC Monograph Series).
- Hochstapler Leander Tomarkin: Der Erfinder des "Antimicrobum" - SPIEGEL ONLINE;
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Drusen formation occurs in the region of the fracture membrane, or more precisely in its extracellular matrix. This and a diffuse membrane thickening lead to an undersupply of the RPEs.
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Antigen-presenting and phagocytically active cells macrophages and dendritic cells are attracted by the oxidized fraction membrane components. The neovascularizations reach the retinal layers after breaking through the fracture membrane. Leakage from abnormal blood vessels can result in fluid accumulation. The affected patient notices this as metamorphopsia. Bleeding and scarring can result in rapid vision loss Source 6.
Modern diagnostic and therapeutic procedures intravitreal injections, dietary supplements have given patients hope in recent years because the disease process can be slowed down.
We will discuss the various therapy modalities in more detail in the other blog posts. A current study is investigating the use of a biologically designed composite implant California Project to Cure Blindness-Retinal Pigment Epithelium, Source 1. This consists in part of a polarized monomolecular RPE layer derived from human embryonic stem cells.
This layer rests on a synthetic parylene layer, which is modeled on the fracture membrane. The implant was successfully inserted in 4 of the 5 study patients. Using OCT optical coherence tomography diagnostics, the correct use of the implant was tested and integration of the new photoreceptors was confirmed. The 4 successfully implanted study participants showed no further reduction in visual acuity during the course of the study.
One of these patients even showed a gain of 17 letters. Improved fixation was observed in two study eyes.
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A very interesting and innovative study. The question arises as to whether she can lay the foundation for healing? We are eagerly awaiting the long-term results. Sources: 1. Ambati J. Mechanisms of age-related macular degeneration. Finger, R. The i ncidence of blindness and severe visual impairment in Germany: projections for Invest Ophthalmol Vis Sci, Friedman D.